WebMay 21, 2024 · FOXO3a is a member of the FOXO transcription factor family, which plays a pivotal role in maintaining redox balance. Activation of the SIRT1/FOXO3a pathway can inhibit oxidative stress primarily by regulating antioxidant enzymes [ [13], [14], [15] ]. WebDec 1, 2016 · For example, FoxO3a activates FasL transcription, the ligand for the Fas-dependent cell death pathway or pro-apoptotic Bim gene and initiates apoptosis. FoxO3a also induces the expression of cell cycle progression inhibitors including p27 and CyclinD1, thus stalling the G1/S phase transition . Here, we investigated whether the survival …
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WebJan 15, 2024 · The 14-3-3 proteins bind to the phosphorylated FoxO3a at Thr32 and Ser253. Binding of 14-3-3 proteins to FoxO3a prevents the cytoplasmic pool of FoxO3a … WebSep 25, 2024 · The protein stability of FOXO3A is regulated by Casein Kinase 1 alpha (CK1α) in an oncogenic RAS-specific manner, but whether this mode of regulation extends to related FOXO family members is ... dying light find the tunnel out of the slums
Introduction to FOXO Biology - PubMed
WebMonoclonal Antibody for studying FoxO3a. Cited in 446 publications. Validated for WB, IP, IF. Highly specific and rigorously validated in-house, FoxO3a (75D8) Rabbit Monoclonal … WebFOXO3a is a transcription factor of the FOXO family. The FOXO proteins participate in multiple signaling pathways, and their transcriptional activity is regulated by several post … WebForkhead box O (FOXO) proteins are a family of transcription factors with four members in mammals, namely FOXO1, FOXO3a, FOXO4, and FOXO6. FOXO factors, originally identified as downstream regulators of the insulin pathway, are known to bind to the promoters of a broad variety of target genes and co … Introduction to FOXO Biology dying light find the meteor samples