Hif-2alpha kidney disease
WebNational Center for Biotechnology Information WebPersistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium. K. Eckardt, M. Gräfe, P. Maxwell, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Persistent induction of HIF‐1α and ‐2α in cardiomyocytes ...
Hif-2alpha kidney disease
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Web26 de jan. de 2024 · Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are impaired due to insufficient activation of HIF signalling, which results from inhibition of HIF-1α stability and function due to hyperglycaemia and … Web5 de dez. de 2024 · Anemia is a common feature and complication of chronic kidney disease (CKD). Erythropoiesis-stimulating agents (ESAs) and recombinant human …
Web25 de mai. de 2024 · 5003 Background: Patients (pts) with Von Hippel-Lindau disease (VHL) are at risk for several cancers, including clear cell renal cell carcinoma (ccRCC). Inactivation of VHL results in constitutive activation of the HIF-2α transcription factor, which drives tumor growth. MK-6482, a potent, selective, small molecule HIF-2α inhibitor, has … Web5 de dez. de 2024 · Anemia is a common feature and complication of chronic kidney disease (CKD). Erythropoiesis-stimulating agents (ESAs) and recombinant human erythropoietin have been used widely in renal anemia treatment. Recently, hypoxia-inducible factor-prolyl hydroxylase domain inhibitors (HIF-PHIs) that may improve the …
Web6 de jun. de 2015 · Unexpectedly, one study of inactivation of HIF-2alpha in endothelial cells ... However, given on-going trials of these agents in anaemia associated with kidney disease, it is of interest that reduced blood pressure has been reported in a rat model of chronic kidney injury after exposure to the compound, BAY85-3934. 96. WebThe Lancet The best science for better lives
Web6 de jul. de 2016 · It is generally accepted that renal hypoxia plays an important role in the progression of chronic kidney disease (CKD). This review focuses on renal hypoxia and …
Web6 de jan. de 2024 · HIF-2alpha inhibitor has been tested in 55 individuals with heavily pre-treated metastatic RCC. It resulted in a median objective response rate of 24% and a … cynwyd north walesWeb22 de nov. de 2024 · Renal fibrosis is the final manifestation of chronic kidney disease (CKD) regardless of etiology. Hypoxia-inducible factor-2 alpha (HIF-2α) is an important … biminis ft myersWeb12 de jan. de 2024 · Introduction. Chronic kidney disease (CKD), as a major global health problem, is estimated to affect 8–16% of adult populations globally (Stanifer et al., 2016; Chen et al., 2024).Anemia, which is frequently observed in CKD, is not only a highly prevalent risk factor for many adverse events in CKD patients but also contributes to the … bimini restaurant ft myersWeb11 de abr. de 2024 · Anemia is a common complication of chronic kidney disease and presents more than 90% prevalence in patients on dialysis, contributing to significant morbidity and mortality [1]. ... HIF-2alpha, but not HIF-1 alpha, promotes iron absorption in mice. J. Clin. Invest., 119 (5) (2009), pp. 1159-1166. View in Scopus Google Scholar cynwyd heritage trailWebHIFs are now postulated to play contrasting protective and pathogenic roles in acute and chronic kidney diseases, respectively. In this review, we discuss the mechanisms of … bimini seaplane from miamiWeb1 de mai. de 2007 · Immunostaining with markers of oxidative stress showed enhanced oxidative stress in the kidney of HIF-2alpha knockdown mice, which was associated with peritubular capillary loss. biminis fort myers flWeb9 de mai. de 2008 · To further examine the molecular regulation of the Abcg2 gene, we demonstrated that hypoxia-inducible factor (HIF)-2alpha binds an evolutionary conserved HIF-2alpha response element in the murine Abcg2 promoter. Transcriptional assays reveal a dose-dependent activation of Abcg2 expression by HIF-2alpha. bimini shade for boat