WebMyrf is a pleiotropic membrane-bound transcription factor that plays critical roles in diverse organisms, including in oligodendrocyte differentiation, embryonic development, molting, … WebNov 1, 2024 · This particular combination of transcription factors yielded activation rates for each of the regulatory regions that were substantially higher than obtained in parallel transfections for either KLF9 and SOX10 or SOX10 and MYRF (Figure 4J– L). The magnitude of the obtained cooperative effect was impressive for all analysed regulatory regions.
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WebFeb 12, 2024 · Orthologous to human MYRF (myelin regulatory factor). [provided by Alliance of Genome Resources, Apr 2024] Myrf myelin regulatory factor [ (house mouse)] Gene ID: 225908, updated on ... results thus suggest that Fbxw7 controls the transcription of MyRF target genes in various tissues through regulation of MyRF protein stability in a manner ... WebThe fact that Dusp15 is a common target of Egr2 and Myrf transcription factors suggested that it may have an important common role in both Schwann cells and oligodendrocytes. While the direct targets of Dusp15 phosphatase activity are not resolved in this work, we show evidence for its regulation of the Erk1/2 pathway in Schwann cells. cells are the basic unit of life and what
MYRF: A Mysterious Membrane-Bound Transcription …
WebDe novo variants in the myelin regulatory factor (MYRF), a transcription factor involved in the differentiation of oligodendrocytes, have been linked recently to the cardiac and … MyRF is a transcription factor that promotes the expression of many genes important in the production of myelin. It is therefore of critical importance in the development and maintenance of myelin sheaths. The expression of MYRF is specific to mature, myelinating oligodendrocytes in the CNS. It has been … See more Myelin regulatory factor (MyRF), also known as myelin gene regulatory factor (MRF), is a protein that in humans is encoded by the MYRF gene. See more Myelin regulatory factor is encoded by the Myrf/GM98 gene in mice and by the MYRF gene in humans. The family of MyRF-like-proteins also contains the orthologues pqn-47 from See more Mice that lose MYRF during adulthood present with a severe demyelination similar to that seen in animal models of multiple sclerosis. This underlines the importance of an … See more WebApr 9, 2024 · It is known that N-terminal fragment of MYRF (nMYRF) is generated by cleavage of full-length MYRF in the cytoplasm and then moves into nucleus to activate myelin gene transcription in oligodendrocytes 24, 25. We then investigated whether LAQ influences the interaction of mutant HTT with MYRF to prevent its inhibitory effect on … buyers products lt12