WebLinezolid. Molecular Formula CHFNO. Average mass 337.346 Da. Monoisotopic mass 337.143799 Da. ChemSpider ID 390139. - 1 of 1 defined stereocentres. WebAug 13, 2024 · Postmarketing side effects of linezolid reported include: superficial tooth discoloration. superficial tongue discoloration. low blood platelet count. low white blood cell count. reduced white, red, and platelet blood cell count. platelet deficiency in the blood. numbness and tingling in arms and legs. damage to the nerve of the eye.
Linezolid: MedlinePlus Drug Information
At physiological pH (7.4), linezolid exists in an uncharged state. It is moderately water-soluble (approximately 3 mg/mL), with a logP of 0.55. The oxazolidinone pharmacophore—the chemical "template" essential for antimicrobial activity—consists of a 1,3-oxazolidin-2-one moiety with an aryl … See more Linezolid is an antibiotic used for the treatment of infections caused by Gram-positive bacteria that are resistant to other antibiotics. Linezolid is active against most Gram-positive bacteria that cause disease, including See more Linezolid is a weak, non-selective, reversible monoamine oxidase inhibitor (MAOI), and should not be used concomitantly with other MAOIs, large amounts of See more Acquired resistance to linezolid was reported as early as 1999, in two patients with severe, multidrug-resistant Enterococcus faecium infection … See more The main use of linezolid is the treatment of severe infections caused by aerobic Gram-positive bacteria that are resistant to other antibiotics; it should not be used against bacteria that … See more When used for short periods, linezolid is a relatively safe drug. Common side effects of linezolid use (those occurring in more than 1% of people taking linezolid) include diarrhea (reported … See more Pharmacodynamics Linezolid, like other oxazolidinones, is a bacterial protein synthesis inhibitor and a weak, non-selective, reversible monoamine oxidase inhibitor. As a protein synthesis inhibitor, linezolid stops the growth and reproduction of … See more The oxazolidinones have been known as monoamine oxidase inhibitors since the late 1950s. Their antimicrobial properties were discovered by researchers at E.I. duPont de Nemours in … See more imeche royal navy
Pharmacokinetics and penetration of linezolid into inflamed
WebThe volume of distribution of linezolid at steady-state averaged 40 to 50 liters in healthy adult volunteers. Linezolid concentrations have been determined in various fluids from a … http://editor.fresenius-kabi.us/SDSSheets/US-PH-Linezolid_Inj_FK-2024v1-SDS.pdf WebJul 10, 2024 · The degradation rates of linezolid at selected pH values at 70.0°C and the influence of ionic strength were also examined. Activation energy data were applied to … imeche scottish region dinner 2022