WebAutophagy requires a direct association between Atg1 and Atg13, and is inhibited by TOR-dependent phosphorylation of Atg13 under high-nutrient conditions (5). Similarly, mammalian Atg13 forms a complex with the Atg1 homologues ULK1/2, along with FIP200, which localizes to autophagic isolation membranes and regulates autophagosome … WebApr 2, 2013 · Autophagy-related 13 (Atg13) is a key early-acting factor in autophagy and the major locus for nutrient-dependent regulation of autophagy by Tor. The 2.3-Å resolution crystal structure of the N-terminal domain of Atg13 reveals a previously unidentified HORMA (Hop1p, Rev1p and Mad2) domain similar to that of the spindle checkpoint protein Mad2.
The role of the Atg1/ULK1 complex in autophagy regulation
WebApr 1, 2010 · Rapamycin, an inhibitor of (m)TOR can activate autophagy even under nutrient rich conditions. Rapamycin treatment rapidly induces Atg13 dephosphorylation and promotes Atg1–Atg13–Atg17 complex formation in yeast [13••, 22•]. However, it remains unknown whether Tor directly phosphorylates Atg13. WebDec 7, 2009 · Atg13 is phosphorylated in a Tor-dependent manner, and when isolated from cells under nutrient-rich conditions, Atg13 migrates more slowly by SDS-PAGE, suggesting … mini cooper bluetooth upgrade 2005
A HORMA domain in Atg13 mediates PI 3-kinase recruitment in …
WebMay 13, 2024 · Further analysis showed that PpSnRK1α not only activated autophagy by inhibiting target of rapamycin (TOR) signaling but also enhanced ABA-induced autophagy. This indicates that PpSnRK1α regulates the photosynthetic rate and induces autophagy, and then responds to low nutrient stress. ... The ATG1/ATG13 protein kinase complex is both … WebAutophagy-related protein 13. Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene. [5] ATG13 is an autophagy factor required for phagosome formation. ATG13 is a target of the TOR kinase signaling pathway that regulates autophagy through phosphorylation of ATG13 and ULK1, and the ... WebAug 18, 2009 · The serine-threonine kinase Atg1 was first identified in yeast screens for essential Autophagy (Atg) genes ().Further work solidified Atg1 as a dynamic signaling … mini cooper bmw seattle